Talk to your doctor before taking this medicine, if you:

• are allergic to temozolomide or any of the other ingredients of this medicine
• have had an allergic reaction to dacarbazine (an anticancer medicine sometimes called DTIC)
• have severely reduced blood cells (myelosuppression), such as your white blood, red blood and platelet count
• have serious form of chest infection called Pneumocystis jirovecii pneumonia (PCP)
• have ever had or might now have a hepatitis B infection
• may have a small risk of other changes in blood cells, including leukaemia
• more prone to infections, bruising or bleeding
• have liver or kidney problems

• Effective contraceptive precautions must be taken by patients who are taking GLIOZOLAMIDE 250MG
• You should stop breast-feeding while receiving treatment with GLIOZOLAMIDE 250MG
• If you are pregnant, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine

• Do not give this medicine to children under the age of 3 years because it has not been established

• GLIOZOLAMIDE 250MG may make you feel tired or sleepy. In this case, do not drive or use any tools or machines or cycle until you see how this medicine affects you

• a severe allergic (hypersensitive) reaction (hives, wheezing or other breathing difficulty)
• uncontrolled bleeding
• seizures (convulsions)
• fever, chills
• severe headache that does not go away
• a reduction in certain kinds of blood cells. This may cause you to have increased bruising or bleeding, anaemia (a shortage of red blood cells), fever, and reduced resistance to infections

• infections, wound infection
• increased sugar in the blood, loss of weight
• change in mental status or alertness, anxiety/depression, sleepiness, difficulty speaking, impaired balance, dizziness, confusion, forgetfulness, difficulty concentrating
• inability to fall asleep or stay asleep, tingling sensation, bruising, shaking, abnormal or blurry vision, double vision
• hearing impairment
• shortness of breath, cough
• blood clot in the legs, fluid retention, swollen legs
• stomach upset
• difficulty swallowing, dry mouth
• skin irritation or redness, dry skin, itching
• muscle weakness, painful joints, muscle aches and pains
• frequent urination, difficulty with holding your urine
• allergic reaction, fever,
• radiation injury, face swelling, pain
• abnormal taste
• reduced number of blood cells (neutropenia or lymphopenia, thrombocytopenia)

• flu-like symptoms, red spots under the skin
• low potassium level in the blood, weight gain
• mood swings, hallucination and memory impairment, partial paralysis, impaired coordination, impaired sensations, partial loss of vision
• dry or painful eyes, deafness, infection of the middle ear, ringing in the ears, earache, palpitations (when you can feel your heart beat)
• blood clot in the lung, high blood pressure, pneumonia, inflammation of your sinuses, bronchitis, a cold or the flu
• swollen stomach, difficulty controlling your bowel movements, haemorrhoids
• peeling skin, increased skin sensitivity to sunlight, change in skin colour, increased sweating
• muscle damage, back pain
• vaginal bleeding, sexual impotence, absent or heavy menstrual periods, vaginal irritation, breast pain
• hot flushes, shivering, discoloration of your tongue, change in your sense of smell, thirst, tooth disorder

• cough, infections including pneumonia

• skin redness, urticaria (hives), skin eruption, allergic reactions

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• Keep this medicine out of reach of children
• Do not use this medicine after the expiry date
• Store at room temperature (15-25C)