Talk to your doctor before taking this medicine, if you:

• are allergic (hypersensitive) to LENZEST 25MG or any of the other ingredients of this medicine
• have had blood clots in the past
• have any signs of an infection, such as a cough or fever
• have or ever had previous viral infection, particularly hepatitis B infection, varicella zona, HIV
• have kidney problems
• have had a heart attack
• have MDS, you may be more likely to get a condition called acute myeloid leukemia (AML)

• LENZEST 25MG should not be taken in pregnant, as it is expected to be harmful to an unborn baby
• You must not become pregnant while taking LENZEST 25MG. Therefore, you must use effective methods of contraception if you are a woman of childbearing potential
• You must not breast-feed when taking LENZEST 25MG, as it is not known if LENZEST 25MG passes into human milk

• LENZEST 25MG is not recommended for use in children and adolescents under 18 years

• Do not drive or operate machines if you feel dizzy, tired, sleepy, have vertigo or blurred vision after taking LENZEST 25MG

• reduce the number of white blood cells, blood cells which help the blood to clot (platelets) which may lead to bleeding disorders such as nosebleeds and bruising
• blood clots in the veins (thrombosis).
• fever, chills, sore throat, cough, mouth ulcers or any other symptoms of infection including within the bloodstream (sepsis)
• bleeding or bruising in the absence of injury
• chest pain or leg pain
• shortness of breath

• a fall in the number of red blood cells which may cause anemia leading to tiredness and weakness constipation, diarrhoea, nausea, redness of skin, rashes, vomiting, muscle cramps, muscle aches, bone pain, joint pain, tiredness, generalized swelling including swelling of your arms and legs
• decreased appetite, low levels of potassium in the blood, leg pain, chest pain or shortness of breath
• infection of the lungs, upper respiratory tract, shortness of breath
• blurred vision, clouding of your eye (cataract)
• kidney problems
• changes to a protein in the blood that can cause swelling of the arteries (vasculitis)
• increases in your blood sugar level (diabetes)
• increase in pain, tumor size, redness around the tumor
• increased blood pressure or a fall in blood pressure, slow, fast or irregular heart beat
• difficulty getting an erection
• stroke, fainting, muscle weakness, joint swelling
• changes to blood thyroid hormone, low levels of calcium, phosphate or magnesium in the blood
• depression, deafness, abnormal liver test results, impaired balance, difficulty moving, ringing in the ears (tinnitus)
• an excess of iron in the body
• thirst, confusion, toothache, weight loss

• bleeding within the skull
• circulatory problems
• loss of vision
• loss of sex drive (libido)
• passing large amount of urine with bone pain and weakness, which may be symptoms of a kidney disorder (fanconi syndrome)
• stomach pain, bloating marked by inflammation in the large intestine (called colitis or caecitis)
• renal tubular necrosis

• tumour lysis syndrome - high potassium, phosphorus, uric acid, and low calcium consequently leading to changes in kidney function, heartbeat, seizures, and sometimes death

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• Protect from excess heat and light
• Keep this medicine out of reach of children
• Store at room temperature (15-25C)
• Do not use this medicine after the expiry date