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What is MAZETOL?
- MAZETOL contains carbamazepine which belongs to an anti-convulsant medicine (prevents fits)
CONSUMER MEDICINE INFORMATION
THERAPEUTIC USES
WARNING & PRECAUTIONS
INTERACTIONS
DIRECTIONS FOR USE
SIDE EFFECTS
MORE INFORMATION
Talk to your doctor before taking this medicine, if you:
- are allergic to carbamazepine, oxcarbazepine or to any of the other ingredients in this medicine
- have any heart problems
- have ever had problems with your bone marrow
- have a blood disorder called porphyria (an inherited enzyme disorder)
- have any mental illness
- have taken drugs called monoamine oxidase inhibitors (MAOIs), used to treat depression, within the last 14 days
- have liver problems
- have kidney problems
- are elderly
- have eye problems such as glaucoma (increased pressure in the eye)
- have difficulty in retaining urine
- Talk to your doctor if you are pregnant or planning to become pregnant or are breast feeding before taking this medicine
- MAZETOL can make you feel dizzy or drowsy, or may cause blurred vision, double vision, or you may have a lack of muscular coordination, especially at the start of treatment or when the dose is changed
- If you are affected in this way, or if your eyesight is affected, you should not drive or operate machinery
Tell your doctor if you are taking,
- hormone contraceptives, e.g. pills, patches, injections or implants
- hormone replacement therapy such as tibolone
- corticosteroids (‘steroids’)
- anticoagulants such as warfarin
- antibiotics and medicines to treat TB (tuberculosis) such as doxycycline, rifampicin, erythromycin
- antifungals such as itraconazole, fluconazole, ketoconazole or voriconazole
- painkillers containing paracetamol, dextropropoxyphene, tramadol, methadone or buprenorphine
- other antiepileptics such as clobazam, clonazepam, phenytoin, phenobarbitone, primidone, tiagabine, lamotrigine
- antihistamines (medicines to treat allergies) such as loratadine or terfenadine
- diuretics (‘water’ tablets) e.g. furosemide, hydrochlorothiazide
- cimetidine or omeprazole (medicines to treat gastric ulcers)
- isotretinoin (medicine for the treatment of acne)
- aprepitant or metoclopramide (medicines often used to treat sickness)
- acetazolamide (medicine to treat glaucoma – increased pressure in the eye)
- danazol or gestrinone (medicines for the treatment of endometriosis)
- theophylline or aminophylline (medicines for the treatment of asthma)
- cyclosporin, tacrolimus or sirolimus (immunosuppressants, medicines used after transplant operations, but also sometimes in the treatment of arthritis or psoriasis)
- medicines to treat cancer such as toremifene, cisplatin or doxorubicin
- anti-malaria medicine mefloquine (medicine used to treat malaria)
- medicines to treat HIV known as protease inhibitors such as indinavir, saquinavir or ritonavir thyroxine (medicine used to treat hypothyroidism)
- tadalafil (medicine used to treat impotence)
- albendazole (medicine used to treat worms)
- bupropion (medicine used to help stop smoking)
- St. Johns wort (Hypericum perforatum)
- medicines or supplements containing vitamin B such as nicotinamide
- Always take this medicine exactly as your doctor has told you
- The dose needed varies between patients
- Shake the bottle before you measure out your dose
- You are usually told to take a dose two or three times a day
- MAZETOL is given orally, either before, during or between meals
Epilepsy
- Adults: The usual dose is 800-1,200 mg a day, although higher doses may be necessary
- Elderly: You might need a lower dose
- Children aged up to and over 1 year: usually 10-20 mg/kg body weight daily in several divided doses. Your doctor will tell you how much liquid the child should take
Trigeminal neuralgia
- The usual dose is 600-800 mg a day. The maximum dose is 1,200 mg a day. If you are elderly you might require a lower dose. Once the pain is controlled, your doctor will probably reduce the dose
Mood swings
- The usual dose is 400-600 mg a day
If you take more MAZETOL
- If you accidentally take too much MAZETOL, tell your doctor or your nearest hospital casualty department
If you forget to take MAZETOL
- If you forget to take a dose, take one as soon as you remember
- Do not take a double dose to make up for a forgotten dose
If you stop taking MAZETOL
- Do not stop taking your medicine suddenly, as this may result in you having a seizure. Only stop taking your medicine if your doctor tells you to do so
Like all medicines, this medicine can cause side effects, although not everybody gets them.
SERIOUS
COMMON
UNCOMMON
RARE
VERY RARE
- serious skin reactions such as rash, red skin, blistering of the lips, eyes or mouth, or skin peeling accompanied by fever
- changes in the blood, including unexplained bleeding or bruising, or making it easier to catch infections with mouth ulcers, sore throat, or high temperature
- liver problems or failure, including jaundice with yellowing of your skin or the whites of your eyes.
- swollen ankles, feet or lower legs
- any signs of nervous illness or confusion
- pain in your joints and muscles, a rash across the bridge of the nose and cheeks and problems with breathing
- bronchospasm with wheezing and coughing, difficulty in breathing, feeling faint, rash, itching or facial swelling (these may be the signs of a severe allergic reaction)
- pain in the area near the stomach
- reactivation of herpes virus infection (can be serious when immune system is depressed)
- dizziness
- drowsiness
- tiredness
- feeling unsteady or finding it difficult to control movements
- changes in liver enzyme levels (usually without any symptoms)
- skin reactions, including urticaria (hives), which may be severe
- fluid retention and swelling
- weight increase
- low sodium in the blood which might result in confusion
- headache
- double or blurred vision
- dry mouth
- abnormal involuntary movements including tremor or tics
- abnormal eye movements
- diarrhoea
- constipation
- disease of the lymph glands
- folic acid deficiency (can be detected with a blood test by your doctor)
- hallucinations
- depression
- loss of appetite
- restlessness
- aggression
- agitation
- confusion
- speech disorders
- numbness or tingling in the hands and feet
- muscle weakness
- high blood pressure (which may make you feel dizzy, with a flushed face, headache, fatigue and nervousness)
- low blood pressure (the symptoms of which are feeling faint, light headed, dizzy, confused, having blurred vision)
- changes in heart beat
- stomach pain
- changes to the composition of the blood including anaemia
- porphyria
- meningitis (inflammation of the brain lining)
- swelling of the breasts and discharge of milk which may occur in both male and females
- abnormal thyroid function tests
- osteomalacia (which may be noticed as pain on walking and bowing of the long bones in the legs)
- osteoporosis (brittle bones)
- increased blood fat levels
- taste disturbances
- conjunctivitis (red eyes)
- glaucoma (increased pressure in the eyes)
- cataracts
- hearing disorders
- heart and circulatory problems including deep vein thrombosis (DVT), the symptoms of which could include tenderness, pain, swelling, warmth, skin discoloration and prominent superficial veins
- sore mouth or tongue
- hair loss
- increased hair growth on the body and face
- muscle pain or spasm
- sexual difficulties which may include reduced male fertility
- loss of libido or impotence
- kidney failure
- blood spots in the urine
- increased or decreased desire to pass urine or difficulty in passing urine
